January 2022
Platelet-rich fibrin as palatal bandage in gingival graft harvest: a systematic review and meta-analysis
Abstract
Aim: To systematically review the effects of platelet-rich fibrin applications on the palatal wounds of patients undergoing gingival graft harvest. Materials and Methods: An electronic search was performed (May 2020) in six databases: Cochrane Library, EMBASE, LILACS, PubMed, Scopus, and Web of Science. Pain and delayed bleeding were the outcomes assessed. The randomized clinical trials were submitted to risk analysis of bias (RoB 2.0 Cochrane Collaboration), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessed the quality of scientific evidence. Results: From the ten studies included, the majority showed unclear or high risk of bias. Patients who received PRF had lower pain scores within 7-13 days (SMD = -3.01; 95% CI = -5.22 - -0.80; I2 = 95%). The PRF group showed no statistically significant difference in delayed bleeding outcome (RR = 0.38; 95% CI = 0.05 - 3.18; I2= 80%). For both outcomes, GRADE analysis showed a low quality of scientific evidence. Conclusion: Despite the limited evidence currently available, analysis found that PRF can reduce postoperative pain, enabling a postoperative period more comfortable for the patient, but does not decrease the risk of delayed bleeding.
Other articles in this issue
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| Machine learning identification of periodontitis patients and their subgingival microbial features Natalia Sánchez-Lopera, Manuela Restrepo-Posada, Sthefania Gutiérrez-González, David Ortega-Valderrama, Sandra Amaya-Sánchez, Adolfo Contreras, Andrés Felipe Gutiérrez, Leonardo A. Pachon, Javier Enrique Botero | Download |
| Epidemiology of periodontitis in Brazilian adults: an integrative literature review of large and representative studies Tayse Caroline Cunha de Medeiros, Alessandra Areas e Souza, Alex Nogueira Haas, João Paulo Steffens | Download |
| Effect of age on expression of osteoclastogenic bone biomarkers in periodontal surgical treatment outcomes Priyanka Gupta, Rameshwari Singhal, Pavitra Rastogi, Nand Lal, Anjani Kumar Pathak, Shivani Pandey, Abbas Ali Mahdi | Download |
| Correlation of periodontal ligament associated protein-1 and tumour necrosis factor – alpha levels in gingival crevicular fluid and serum in periodontal health and diseased subjects before and after nonsurgical periodontal therapy Ankitha Menon, Athira Jayan, AR Pradeep | Download |
| Factors affecting demand for dental implant treatment: a patient-centered observational study Nil Yakar, Onurcem Duruel, Güliz N. Güncü, Erdem Karabulut, Nermin Yamalik | Download |
| Antibiotics plus probiotic as an adjunct to the treatment of periodontitis in smokers: a short-term study Leticia H. Theodoro, João M. Mello-Neto, Marina M. Cláudio, Marta A. A. Nuernberg, Daniela M. J. Miessi, Beatriz G. Silva, João Victor S. Rodrigues, Daniela A. Brandini, Valdir G. Garcia | Download |
| Subgingival irrigation with phytotherapics adjunct to scaling and root planing on the treatment of experimental periodontal disease in rats Carolina dos Santos Santinoni, Marcela Lucio Caldeira, Taciane Menezes da Silveira, Bibiana Dalsasso Velasques, Natália Marcumini Pola, Christine Men Martins, Douglas Roberto Monteiro, Luciana Prado Maia, Edilson Ervolino, Thiago Marchi Martins | Download |
| Vegetarian diet and periodontal status: assessment of clinical measures and gingival fluid inflammatory cytokines Ahmed Khocht, Michael Orlich, Denise Bellinger, Leticia Lenoir, Crissy Irani, Gary Fraser | Download |
| Platelet-rich fibrin as palatal bandage in gingival graft harvest: a systematic review and meta-analysis Agnes Andrade Martins, Jaiane Carmélia Monteiro Viana, Rayrane Iris Melo da Cunha, Luanny de Brito Avelino, Maria Helena Rodrigues Galvão, Cristiano Miranda de Araújo, Karinna Veríssimo Meira Taveira, Gustavo Henrique Apolinário Vieira | Download |
