January 2022
Effect of age on expression of osteoclastogenic bone biomarkers in periodontal surgical treatment outcomes
Abstract
Aim: Age is not considered a prognostic determinant in surgical periodontal treatment planning even though it is a non-modifiable risk factor. Present study explores the effect of age on bone coupling mechanism at molecular level through Osteoprotegrin (OPG) and Receptor activator of nuclear factor kappa-B ligand (RANKL) following surgical pocket therapy in periodontitis. Methods: Forty-five generalized periodontitis patients were divided for surgical treatment into three groups based on age (in years): Group1 (Youth; 16-19); Group 2 (Adult; 25-45); Group 3 (Old; >60). Clinical parameters were evaluated at baseline, 12, and 24 weeks. OPG, RANKL, and its ratio were assessed using Enzyme-linked immunosorbent assay at baseline and 24 weeks. Results: Stringent oral hygiene was maintained in Youth, Adult, and Old age-groups at all-time intervals. At 24 weeks, clinical and bone biomarker levels improved from baseline but the difference was not statistically significant across different age groups (p>0.05). Conclusion: Age has no impact on surgical outcomes at the clinical or molecular bone level as long as oral-hygiene is well maintained and plaque accumulation is limited in post-surgical healing phase.
Other articles in this issue
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| Machine learning identification of periodontitis patients and their subgingival microbial features Natalia Sánchez-Lopera, Manuela Restrepo-Posada, Sthefania Gutiérrez-González, David Ortega-Valderrama, Sandra Amaya-Sánchez, Adolfo Contreras, Andrés Felipe Gutiérrez, Leonardo A. Pachon, Javier Enrique Botero | Download |
| Epidemiology of periodontitis in Brazilian adults: an integrative literature review of large and representative studies Tayse Caroline Cunha de Medeiros, Alessandra Areas e Souza, Alex Nogueira Haas, João Paulo Steffens | Download |
| Effect of age on expression of osteoclastogenic bone biomarkers in periodontal surgical treatment outcomes Priyanka Gupta, Rameshwari Singhal, Pavitra Rastogi, Nand Lal, Anjani Kumar Pathak, Shivani Pandey, Abbas Ali Mahdi | Download |
| Correlation of periodontal ligament associated protein-1 and tumour necrosis factor – alpha levels in gingival crevicular fluid and serum in periodontal health and diseased subjects before and after nonsurgical periodontal therapy Ankitha Menon, Athira Jayan, AR Pradeep | Download |
| Factors affecting demand for dental implant treatment: a patient-centered observational study Nil Yakar, Onurcem Duruel, Güliz N. Güncü, Erdem Karabulut, Nermin Yamalik | Download |
| Antibiotics plus probiotic as an adjunct to the treatment of periodontitis in smokers: a short-term study Leticia H. Theodoro, João M. Mello-Neto, Marina M. Cláudio, Marta A. A. Nuernberg, Daniela M. J. Miessi, Beatriz G. Silva, João Victor S. Rodrigues, Daniela A. Brandini, Valdir G. Garcia | Download |
| Subgingival irrigation with phytotherapics adjunct to scaling and root planing on the treatment of experimental periodontal disease in rats Carolina dos Santos Santinoni, Marcela Lucio Caldeira, Taciane Menezes da Silveira, Bibiana Dalsasso Velasques, Natália Marcumini Pola, Christine Men Martins, Douglas Roberto Monteiro, Luciana Prado Maia, Edilson Ervolino, Thiago Marchi Martins | Download |
| Vegetarian diet and periodontal status: assessment of clinical measures and gingival fluid inflammatory cytokines Ahmed Khocht, Michael Orlich, Denise Bellinger, Leticia Lenoir, Crissy Irani, Gary Fraser | Download |
| Platelet-rich fibrin as palatal bandage in gingival graft harvest: a systematic review and meta-analysis Agnes Andrade Martins, Jaiane Carmélia Monteiro Viana, Rayrane Iris Melo da Cunha, Luanny de Brito Avelino, Maria Helena Rodrigues Galvão, Cristiano Miranda de Araújo, Karinna Veríssimo Meira Taveira, Gustavo Henrique Apolinário Vieira | Download |
