Aim: Age is not considered a prognostic determinant in surgical periodontal treatment planning even though it is a non-modifiable risk factor. Present study explores the effect of age on bone coupling mechanism at molecular level through Osteoprotegrin (OPG) and Receptor activator of nuclear factor kappa-B ligand (RANKL) following surgical pocket therapy in periodontitis. Methods: Forty-five generalized periodontitis patients were divided for surgical treatment into three groups based on age (in years): Group1 (Youth; 16-19); Group 2 (Adult; 25-45); Group 3 (Old; >60). Clinical parameters were evaluated at baseline, 12, and 24 weeks. OPG, RANKL, and its ratio were assessed using Enzyme-linked immunosorbent assay at baseline and 24 weeks. Results: Stringent oral hygiene was maintained in Youth, Adult, and Old age-groups at all-time intervals. At 24 weeks, clinical and bone biomarker levels improved from baseline but the difference was not statistically significant across different age groups (p>0.05). Conclusion: Age has no impact on surgical outcomes at the clinical or molecular bone level as long as oral-hygiene is well maintained and plaque accumulation is limited in post-surgical healing phase.
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