Cure of type II diabetes mellitus by anti-infectious (step 2) periodontal therapy and the reduction of body weight

Authors: Jens Martin Herrmann, Kay-Arne Walther, Negar Mirzabeygi, Joerg Meyle


Type II diabetes mellitus (T2DM) is described as an inflammatory or inflammation-promoted metabolic derangement. Numerous studies demonstrate that elimination of inflammation favorably affects endocrinological parameters in T2DM. Therapy of periodontitis reduces infections of causative microorganisms and eliminates inflammation, preserving successfully treated periodontia and last but not least patients’ teeth. Biofilms are reduced in quantity and influenced in composition. All facilitated by professional, as well as self-care-measures, primarily tooth-surface cleansing and oral-hygiene procedures. Thus, inflammation and affected tissues heal, finally resulting in the regeneration or professional elimination of niches and reservoirs for unfavorable microorganisms. Consequently, it is essential, to prevent infections with periodontal pathogens from flaring up, again. Such an approach is achieved with the concept of periodontal re-infection prevention (RP). Not a new method, RP has already been used successfully in classical studies, after anti-infectious as well as surgical periodontal interventions. Contrastingly, this approach of RP is largely absent from the guidelines for the treatment of periodontitis (Sanz et al., 2020). With this case report, we present the course of treatment of a 60-year-old patient who was cured of his periodontitis (stage 4, grade C) and his T2DM, without any antidiabetic medication. Periodontal, endocrinological and metabolic outcomes are discussed.

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