October 2022
Efficacy of Chlorhexidine, Metronidazole and Combination Gel in the Treatment of Gingivitis - A Randomized Clinical Trial
Abstract
Objective: Effective plaque control is essential for prevention of gingivitis and periodontitis. The aim of this 24-week follow-up parallel study was to evaluate the efficacy of three topical gels in the treatment of gingivitis as compared to placebo gel. Methods: One hundred twenty subjects diagnosed with chronic generalized gingivitis were selected and randomly divided into four groups: Group 1 – placebo gel, Group 2 – chlorhexidine (CHX) gel, Group 3 – metronidazole (MTZ) gel and Group 4 – chlorhexidine-metronidazole (CHX-MTZ) gel. Clinical evaluation was undertaken using the gingival index (GI) of Löe and Silness and the plaque index (PI) at baseline, 6 weeks, 12 weeks and 24 weeks. Microbiological analysis was also done at the same time intervals. A subjective evaluation was also undertaken by questionnaire. Results: Groups treated with all three gels (CHX, MTZ and CHX-MTZ) showed significant clinical and microbiological improvement as compared to the group treated with a placebo gel. The reduction in PI, GI and microbiological count in the group treated with the CHX-MTZ combination gel was significant when compared to those treated with CHX and MTZ gels. Conclusion: Topical application of CHX or MTZ alone or in combination may have a role in the management of gingivitis.
Other articles in this issue
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| Relationship between gingival crevicular trappin-2 and gingipain levels in periodontal health and disease - An observational report Pavithra Durgesh, Srikumar Prabhu, Srirangarajan Sridharan, Ravi Rao, Shashidara Raju, Oradiyath Deepika | Download |
| Characterization of the human root dentin, in the use of EDTA 24%. Intercalated or continuous application? Anne Karoline Fernandes de Matos, Fernanda Aparecida Silva, Tomaz Gonçalves Martins Neto, Priscila dos Santos Simões, Gabriel Gonçalves Amaral, Fernando Antônio Mauad de Abreu | Download |
| A comparative evaluation of non-incised papillae and entire papilla preservation surgical approaches in treatment of intrabony defects – a clinical and radiographic study Vallabhdas Santosh, Vallabhdas Santosh, Bandi Divya Elenora Martina, Rampalli Viswa Chandra, Aileni Amarender Reddy | Download |
| Efficacy of recombinant human fibroblast growth factor-2 (rhfgf-2) impregnated absorbable collagen scaffold in sites with multiple gingival recession defects Viswa Chandra Rampalli , Rajini Kandikatla, Sneha Kidambi, Santosh Vallabhdas, Amarendhar Reddy Aileni | Download |
| Association of periodontitis and psoriasis: a systematic review and meta-analysis Maiara Rodrigues de Freitas, Fabiana Martins de Oliveira Campos, Isabelle Schalch de Oliveira Campos, Victor Silva Mendes, Monique Vieira Furukawa, Fernando O Costa, José R Cortelli, Emanuel Silva Rovai, Sheila Cavalca Cortelli | Download |
| Proof of Principle: human histologic demonstration of socket healing with socket shield and grafting using non-demineralized autologous tooth dentin graft Snježana Pohl, Narayan Tondikulam Venkataraman, Jelena Tomac | Download |
| Cure of type II diabetes mellitus by anti-infectious (step 2) periodontal therapy and the reduction of body weight Jens Martin Herrmann, Kay-Arne Walther, Negar Mirzabeygi, Joerg Meyle | Download |
| Somatosensory evaluation of donor and recipient sites of subepithelial connective tissue graft: case-control preliminary study Talyta Sasaki Jurkevicz, Yuri Martins Costa, Matheus Völz Cardoso, Carla Andreotti Damante, Adriana Campos Passanezi Sant’Ana, Leonardo Rigoldi Bonjardim, Mariana Schutzer Ragghianti Zangrando | Download |
| Painless osteoid osteoma over anterior hard palate: A case report and review of literature Nishat Sultan, Mohammad Faisa, Zeba Jafri, Madhuri Sawai, Ashu Bhardwaj | Download |
| Alveolar ridge and keratinized gingiva preservation using collagen matrix and inorganic bone substitute in flapless extractions: A case series of exposed biomaterials Mariana Moraes de Souza, Cristhiam de Jesus Hernandez Martinez, Valessa Florindo Carvalho, Flávia Aparecida Chaves Furlaneto Messora, Daniela Bazan Palioto Bulle, Michel Reis Messora, Sérgio Luís Scombatti de Souza, Arthur Belém Novaes Jr, Mario Taba | Download |
