Objective: The aim of the study was to evaluate the efficacy of calcium phosphosilicate bioactive glass in combination with Platelet Rich Fibrin (PRF) in the treatment of horizontal bone defects in stages II and III periodontitis. Materials and Methods: The randomized controlled trial included 51 sites of horizontal bone defects from 4 patients with stages II and III periodontitis. The three treatment groups were: Group A - open flap debridement (OFD) + bone graft +PRF gel; Group B - OFD+ bone graft+ PRF gel covered by PRF membrane; Group C - OFD alone. The clinical and radiographic parameters were recorded at baseline and 9 months post-surgery. Results: All the three groups showed statistically significant improvement in clinical and radiographic parameters, except for defect width at 9 months post-surgery. Conclusion: The findings of the present study allows to conclude that the use of PRF in combination with bone graft can serve as a promising therapeutic approach for the treatment of horizontal bone defects, resulting in improvement of both clinical and radiographic parameters.
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