Association of hypothyroidism with periodontal disease complexity

Authors: Lisa M. Yerke, Elaine L. Davis, Robert E. Cohen

Abstract

Aim: Hypothyroidism (HT) is an endocrine disorder characterized by insufficient production of thyroid hormones and is associated with alterations in the gastrointestinal microbiome. Periodontitis is characterized by loss of attachment secondary to dysbiotic plaque biofilm. The objective of this retrospective study was to assess the potential association of hypothyroidism and periodontitis. We hypothesized that patients diagnosed with HT would exhibit a greater percentage of teeth with elevated periodontal probing depths. Materials and methods: Following IRB approval, 1,093 dental records initially were reviewed to obtain 832 patients ≥ 35 years-old (1996-2015). After excluding potentially confounding conditions, 538 records were further assessed. Significance was determined using independent sample t-tests adjusted for equality of variances, and chi-square tests of independence. Results: HT patients exhibited 61.4% of teeth with ≥ 5 mm probing depths, while 48.1% of non-HT patients had probing depths ≥ 5 mm (CI[95%]7.9%-18.8%; P<.001). Similarly, the percentage of teeth with ≥ 6 mm probing depths was 36.2% for HT patients, compared to 28.2% of teeth for patients non-HT (CI[95%]3.1%–12.9%; P<.001], approximately 28% greater among patients with HT. Conclusion: A greater proportion of probing depths ≥ 5 mm and ≥ 6 mm was associated with HT patients, suggesting more complex periodontitis. Dentists and endocrinologists might consider screening for HT and periodontitis, respectively, when appropriate.

Download Article

Other articles in this issue

Article
Evaluation of different clinical periodontal protocols for the treatment of combined endo-periodontal lesions: a clinical and CBCT-based 6-month follow up study Carlos Henrique de Sales Dias Santos, Camila Lopes Ferreira, Naira Maria R B Andere, Cassia Fernandes Araujo, Sergio Lucio Pereira de Castro Lopes, Celso Luiz Caldeira, Mauro Pedrine Santamaria, Maria Aparecida Neves Jardini Download
Comparative clinical evaluation of internal mattress sutures vs continuous independent sling sutures on interdental papilla height and periodontal healing in esthetic zone: Randomized Clinical Study Rashmi Suhag, Nishi Tanwar, Shikha Tewari, Rajinder Kumar Sharma, Satish Chander Narula, Isha Goel Download
Tomographic evaluation of palatal mucosa thickness in donor areas of connective tissue grafts filled with collagen matrix: a randomized split-mouth clinical study Thiago Bezerra da Silva, Mauricio Marcelo Harlos, Mike Reis Bueno, Daiane Cristina Peruzzo, Julio Cesar Joly Download
Levels of angiopoietin 2 and high sensitivity c reactive protein in stage III periodontitis with and without type 2 diabetes mellitus – a cross sectional study Nitish Kalra, Deepesh Jaiswal, Sachin Sinha, Santosh Kumar, Swet Nisha, Mahima Sehgal, Soumya Roychaudhuri, Sonender Pal Singh Download
Association of serum vitamin D3 deficiency with stage III periodontitis and periodontal evaluation of deficient individuals after high dose vitamin D3 supplementation Resmi Padmom Gopalakrishnan, Ambili Ranjith Download
Aesthetic gingival depigmentation with ceramic soft tissue trimming bur and diode laser: a randomized controlled trial Phebie Rodrigues, Joann Pauline George, Roxanne Genevieve Azevedo Download
Volumetric Changes in Anterior Maxillary Reconstruction using DBBM Associated with PRF Membrane and Titanium Mesh – case series Samy Tunchel, Graziele Parize, Alberto Blay, Eduardo Felippe Duailibi Neto, Yeon Jung Kim, Debora Pallos Download
Association of hypothyroidism with periodontal disease complexity Lisa M. Yerke, Elaine L. Davis, Robert E. Cohen Download
Are diagnostic inflammatory biomarkers suitable to predict periodontal disease activity after non-surgical periodontal therapy? Sridharan Srirangarajan, Ranjitha Mohan, Ravi J. Rao, Srikumar Prabhu, Oradiyath Deepika Download
The effect of using of i-PRF (injectable platelet rich fibrin) on filling the gap of immediate dental implant in the esthetic zone”: Randomized clinical trial Bassant Mohye, Mohamed S Al Mofty, Ahmed Y Gamal Download