Association of serum vitamin D3 deficiency with stage III periodontitis and periodontal evaluation of deficient individuals after high dose vitamin D3 supplementation

Authors: Resmi Padmom Gopalakrishnan, Ambili Ranjith


Aim: The aim of the present study was to find the association between serum vitamin D3 deficiency and stage III periodontitis. The adjunctive benefit of high dose vitamin D3 supplement in periodontal therapy was also evaluated. Methods: Periodontally healthy and diseased individuals (n= 80, age 42.05± 6.7) were included in the study. Serum Vitamin D3 levels were assessed using electro chemiluminescence immunoassay. Vitamin D3 was correlated with full mouth bleeding score and pocket depth using pearson correlation coefficient. After scaling and root debridement vitamin D3 deficient periodontitis patients were provided 60,000 IU Vitamin D3 /week for 8 weeks. Re-evaluation was done after 2 months. Results: Serum Vitamin D3 deficiency was significantly associated with periodontitis with an odds ratio of 16.24 and 95 % confidence interval of 5.39 – 48.91 (p < 0.01). Highly significant correlation was noticed with Vitamin D3 values and full mouth bleeding score and probing depth. Reduction in the periodontal parameters were higher in those who were supplemented with Vitamin D3 compared to non-supplemented group even-though it was not statistically significant. Conclusion: The present study concludes that serum Vitamin D3 insufficiency is significantly associated with periodontitis. Vitamin D supplementation as an adjunct to mechanical therapy needs further evaluation.

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