Comparative Evaluation of Chitosan Chlorhexidine Mouthwash in Plaque Control: A Preliminary Randomized Controlled Clinical Trial

Authors: Archana Vilasan, Prabhuji Munivenkatappa Lakshmaiah Venkatesh, Karthikeyan Bangalore Varadhan, Joann Pauline George and Akanksha Dubey

Abstract

Aims: The purpose of the present study was to compare the effect of a new mouth wash formulation consisting of chlorhexidine and chitosan on dental plaque and its reduction to that of chlorhexidine or chitosan alone. Materials and Methods: This study was a single-blind randomized clinical trial with a parallel group design of 3 months duration. Patients (20-40 years) who fulfilled the inclusion and exclusion criteria were assigned equally to group 1: chlorhexidine (0.2%), group 2: chitosan (0.5%) or group 3: chlorhexidine - chitosan combination group. The clinical parameters were recorded at baseline, 6weeks and at 3months. All patients received thorough oral prophylaxis and were instructed to rinse with 10ml of mouthwash twice daily for 1 minute. Results: The combination of chitosan and chlorhexidine showed a statistically significant reduction (p<0.05) in plaque indices from baseline at all time intervals when compared to that of chlorhexidine or chitosan alone. Conclusion: Our study demonstrates that by unifying the properties of chitosan and chlorhexidine may result in a superior antiplaque effect than that of chlorhexidine alone.

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